Things that come to mind when reading this verse:
1. It is unwise to scoff at the righteousness of God.
2. The destruction of Sodom by God in response to the wickedness of the people. Their irrationally hostile attitude toward their heavenly visitors sealed their fate. (see Genesis 18-19)
*Genesis 18:20-21 (NKJV)* And the LORD said, “Because the outcry against Sodom and Gomorrah is great, and because their sin is very grave,
I will go down now and see whether they have done altogether according to the outcry against it that has come to Me; and if not, I will know.”
*Genesis 19:24-25 (NKJV)* Then the LORD rained brimstone and fire on Sodom and Gomorrah, from the LORD out of the heavens.
So He overthrew those cities, all the plain, all the inhabitants of the cities, and what grew on the ground.
3. The mocking, rejection, and crucifixion of Christ Jesus, which preceded the destruction of Jerusalem in 70 ad
Matthew 27:27-32, 39-44 (NKJV) Then the soldiers of the governor took Jesus into the Praetorium and gathered the whole garrison around Him.
28 And they stripped Him and put a scarlet robe on Him.
29 When they had twisted a crown of thorns, they put it on His head, and a reed in His right hand. And they bowed the knee before Him and mocked Him, saying, “Hail, King of the Jews!”
30 Then they spat on Him, and took the reed and struck Him on the head.
31 And when they had mocked Him, they took the robe off Him, put His own clothes on Him, and led Him away to be crucified.
39 And those who passed by blasphemed Him, wagging their heads
40 and saying, “You who destroy the temple and build it in three days, save Yourself! If You are the Son of God, come down from the cross.”
41 Likewise the chief priests also, mocking with the scribes and elders, said,
42 “He saved others; Himself He cannot save. If He is the King of Israel, let Him now come down from the cross, and we will believe Him.
43 “He trusted in God; let Him deliver Him now if He will have Him; for He said, ‘I am the Son of God.’ ”
44 Even the robbers who were crucified with Him reviled Him with the same thing.
4. And this:
*Psalm 33:10-12 (NKJV)*
10 The LORD brings the counsel of the nations to nothing; He makes the plans of the peoples of no effect.
11 The counsel of the LORD stands forever, The plans of His heart to all generations.
*12 Blessed is the nation whose God is the LORD, The people He has chosen as His own inheritance.*